Phytochemistry and Biological Activities of Werneria and Xenophyllum species / Fitoquímica y actividades biológicas de especies de Werneria y Xenophyllum

Plants of the genera Werneria (Asteraceae) and Xenophyllum (genus extracted from Werneria) are used in traditional medicine of Latin America for the treatment of mountain sickness, hypertension and gastrointestinal disorders. Only a small number of species of these genera have been studied, leading to the isolation of compounds belonging to the classes of benzofurans, chromenes, acetophenones, coumarates, diterpenes and pyrrolizidine alkaloids. Some of the plant extracts and/or compounds have shown antimicrobial, anti-HIV, hypotensive and photoprotective activities.

Las plantas de los géneros Werneria (Asteraceae) y Xenophyllum (género extraido de Werneria) son usadas en la medicina tradicional de América Latina para el tratamiento del mal de montaña, hipertensión y desórdenes gastrointestinales. Solo un pequeño número de especies de estos géneros ha sido investigado, lográndose aislar compuestos que pertenecen a las clases de benzofuranos, cromenos, acetofenonas, cumaratos, diterpenos y alcaloides pirrolizidínicos. Algunos de los extractos y/o compuestos de dichas plantas han mostrado actividades antimicrobianas, anti-HIV, hipotensoras y fotoprotectoras.

Synthesis of some novel phthalazinone, quinazolinone derivatives and screeing antimicrobial activity of selective compounds

4-[1 H-INDOL-3-YL]-1H-2, 3-benzoxazin-1-one [1] aminolysis with some sulfa drugs and 4-amino-acetophenone to give the corresponding sulfonamide and acetyl phenyl derivatives 2a-c and 3, The key intermediate compound 3 condensed with aromatic aldehyde to yield alpha, beta-unsaturated keto compound 4a, b. Compound 1 reacted with sodium azide to give the tetrazol derivative 5. Benzoxazinone derivative 6 was obtained via the interaction of compound 2 with anthranilic acid, which in turn was condensed with hydrazine hydrate, hydroxyl amine hydrochloride/formamide and glutamic acid to yield quinazolinone derivatives 7, 8, 9 and pentandioic acid derivative 10, respectively. Compound 7 reacted with aromatic aldehyde to achieve the Schiff's bases 11a, b, c. Compound [11c] reacted with thioglycolic acid to give thiazole derivative 12. On the other hand, compound 7 reacted with acetic anhdride to give diacetyl derivative 13. Some of the prepared compounds were screened for their antimicrobial activity

Study of photodynamic reactions of p-nitroacetophenone using ESR and optical techniques.

The photosensitizing properties of p-nitroacetophenone (PNAP), a well-known radiosensitizer, have been studied in near UV region. The mechanism of PNAP photosensitization has been investigated by testing the efficiency of singlet oxygen production using photooxidation of 2,2,6,6-tetramethylpiperidine (TEMP) and photodegradation of guanosine. In both the cases, the enhancement effect of deuterated solvents has been observed. Results of these experiments suggest the significant role of type II mechanisms in PNAP photosensitization.